American Asperger's Association Support Group

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» Chambers of Hope (COH) and American Aspergers Association (AAA)
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» Introductions
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» June 4th 2011
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» Free Home Speech Practice Home offer
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» Support group meeting and hbot volunteers
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» Favor....Locals..read..please...
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» Developmental Disabilities (AAIDD) is hosting the first of its best practices webinars
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» We need to start this website back up again!
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» Group Home Manager is Yelling I Need Help
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» Facebook
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» Support Group Meetings 2011 *EDITED*
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» community happenings!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Jun 22, 2010 6:01 am by asg_tlm@hotmail.com

» Asperger's (how it is diagnosed and treated)
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» What do you do when people look at you by the pills you take vs. the person you are?
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» Items under your nose that are gluten free, and cheap too!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Jun 09, 2010 5:59 am by KelleyNNelson

» Adam
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» Looking for friends
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» Maas-Rowe Carillon Questions
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» Video Emails from Dr. Ron
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» Ah, it's good to be back.
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» 1st Annual Aspergers Volleyball Tournament
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» free event: Therapeutic Recreation Adapted Sailing and Kayak Clinic
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» Help! I Seem to be Getting More Autistic!" ARTICLE
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» Was this teacher out of line?
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» OMG THE PLACE IS REMODELED!!!!
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» Got Plates?
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» Local IEP Advocate!! THANKS VAL!!!
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» Pinellas ESE advisory board meetings
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» Dentists who use sedation.. thanks Dr. Ron
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» Hey GAB!!!!!!!!!!!!!!!!!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Feb 24, 2010 5:25 am by csweepigirl

» Autism in the news: WASHINGTON (Reuters) - A hormone thought to encourage bonding between mothers and their babies may foster social behavior in some adults with autism, French researchers said on Monday.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Feb 18, 2010 7:01 am by csweepigirl

» **********echo*******************
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Jan 31, 2010 11:16 pm by KelleyNNelson

» Any ideas on how to make a gluten regression easier for both child and family?
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» Hi! Long time no see.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Dec 21, 2009 3:04 am by KelleyNNelson

» Hellooooo? Need some freakin' help here.
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» Cats or dogs? Summer or winter?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Nov 23, 2009 6:47 am by man of a million names

» Mozark and the whale *aspergers movie* on showtime on demand.. SUCKED by the way
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Nov 23, 2009 6:42 am by man of a million names

» Adult Aspergers Syndrome
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Nov 22, 2009 4:07 pm by KelleyNNelson

» Asperger’s Syndrome: A Developmental Puzzle by Michael McCroskery
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Nov 22, 2009 12:22 pm by csweepigirl

» Really Cool Super Awesome Thing! Kim And Kelly You Have To Read This!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Nov 20, 2009 4:24 am by man of a million names

» 2 Articles of Interest Re: Aspergers
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Nov 19, 2009 6:15 am by csweepigirl

» Accidently stubled across some info about meletonin oops!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Nov 10, 2009 2:41 pm by csweepigirl

» Lack of Services for ASD
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Nov 09, 2009 8:04 pm by Dr. Ron

» New and having a hard time
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Nov 04, 2009 3:40 am by lovethefish

» Sorry I haven't been around as much (update)
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Nov 03, 2009 10:53 pm by KelleyNNelson

» Having a hard time again
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Oct 20, 2009 8:35 am by man of a million names

» Important paradox/riddle! Anyone care to help with it?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Oct 19, 2009 10:46 pm by KelleyNNelson

» Follow through or not.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Oct 15, 2009 4:01 am by csweepigirl

» New Pediatrics Autism Study Putting Prevalence at 1 in 91
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Oct 14, 2009 11:45 am by csweepigirl

» Different Directions
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Oct 09, 2009 12:41 am by csweepigirl

» AS is a very difficult diagnosis to make.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Oct 08, 2009 1:47 pm by csweepigirl

» How is everyone?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Sep 21, 2009 9:48 pm by Jerry Graham

» CD to benefit the AAA ~!!!!! Check this out!!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Sep 21, 2009 11:14 am by bassfiddlesteve

» I met Joe Diffie's son!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Sep 20, 2009 8:01 am by csweepigirl

» Anyone feel like helping me smack the crap out of my former boss?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Sep 20, 2009 7:56 am by csweepigirl

» Lazy or Aspergers?? or both?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Sep 20, 2009 5:20 am by man of a million names

» The right thing?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Sep 15, 2009 7:27 am by man of a million names

» Mark Fowler and his wonderful work.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Sep 13, 2009 5:51 am by man of a million names

» A.A.A. RESEARCH STUDY. Do you see any differences between females with Aspergers vs. males with Aspergers
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Sep 10, 2009 1:49 pm by csweepigirl

» What happened?? because I don't know, do you?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Sep 10, 2009 6:24 am by man of a million names

» Haha, Funny URL.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Sep 09, 2009 9:15 am by man of a million names

» Dude! Kim, I forgot to tell you... and maybe anyone else at the last meeting...
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSat Sep 05, 2009 4:59 am by man of a million names

» My son is making strange noises!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Sep 04, 2009 11:41 pm by KelleyNNelson

» Terrible sound on video
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Sep 04, 2009 9:30 am by man of a million names

» Aspian or Aspergian?
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» If you, or you know someone who needs a BIG/HUGE carseat..
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» Just a quick hello
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» We started the FLDRS process...and here's what we found out so far
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» Support Groups
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSun Aug 30, 2009 1:31 pm by KelleyNNelson

» (Aspergers) Boy Meets Girl Movie
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Aug 25, 2009 8:13 am by man of a million names

» I give up, with trying to ever just relax, really.. I'm so flustrated!
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» Basic White or Yellow Cake
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» When did this category get here?
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» Pork Fried Rice
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» Why Are The Private Messages Still Disabled????
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» Sorry I've been M.I.A.
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» 5Km Run For AS!
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» Help for a mother.
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Aug 12, 2009 12:01 pm by Dr. Ron

» Aspergers and empathy
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSat Aug 08, 2009 11:41 am by csweepigirl

» We are the three amigo(a)s!Aanyone care to join?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Aug 07, 2009 12:42 am by man of a million names

» Vaccinations, Red Book, What?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeThu Aug 06, 2009 12:21 am by Dr. Ron

» What is the first step?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Aug 05, 2009 7:14 am by Dr. Ron

» Children who can’t cuddle
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeMon Aug 03, 2009 1:27 pm by csweepigirl

» Challenging popular myths about autism
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Jul 31, 2009 10:59 pm by Dr. Ron

» I NEED your HELP!!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeSat Jul 25, 2009 2:41 am by melissa

» Ok..what do I do? any suggestions..
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeFri Jul 24, 2009 3:53 am by melissa

» Back home!
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Jul 22, 2009 2:10 pm by KelleyNNelson

» Any spanish speakers willing to help an aspie in spain?
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeWed Jul 22, 2009 1:34 pm by csweepigirl

» Gluten Free Simple Bread
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Jul 21, 2009 11:49 am by csweepigirl

» More research (genetics)
New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible I_icon_minitimeTue Jul 21, 2009 11:43 am by csweepigirl


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New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible

http://www.sciencedaily.com/releases/2009/04/090401145312.htm

New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible

ScienceDaily (Apr. 2, 2009) — Scientists at Albert Einstein College of Medicine of Yeshiva University have proposed a sweeping new theory of autism that suggests that the brains of people with autism are structurally normal but dysregulated, meaning symptoms of the disorder might be reversible.




The central tenet of the theory, published in the March issue of Brain Research Reviews, is that autism is a developmental disorder caused by impaired regulation of the locus coeruleus, a bundle of neurons in the brain stem that processes sensory signals from all areas of the body.


The new theory stems from decades of anecdotal observations that some autistic children seem to improve when they have a fever, only to regress when the fever ebbs. A 2007 study in the journal Pediatrics took a more rigorous look at fever and autism, observing autistic children during and after fever episodes and comparing their behavior with autistic children who didn't have fevers. This study documented that autistic children experience behavior changes during fever.


"On a positive note, we are talking about a brain region that is not irrevocably altered. It gives us hope that, with novel therapies, we will eventually be able to help people with autism," says theory co-author Mark F. Mehler, M.D., chairman of neurology and director of the Institute for Brain Disorders and Neural Regeneration at Einstein.


Autism is a complex developmental disability that affects a person's ability to communicate and interact with others. It usually appears during the first three years of life. Autism is called a "spectrum disorder" since it affects individuals differently and to varying degrees. It is estimated that one in every 150 American children has some degree of autism.


Einstein researchers contend that scientific evidence directly points to the locus coeruleus–noradrenergic (LC-NA) system as being involved in autism. "The LC-NA system is the only brain system involved both in producing fever and controlling behavior," says co-author Dominick P. Purpura, M.D., dean emeritus and distinguished professor of neuroscience at Einstein.


The locus coeruleus has widespread connections to brain regions that process sensory information. It secretes most of the brain's noradrenaline, a neurotransmitter that plays a key role in arousal mechanisms, such as the "fight or flight" response. It is also involved in a variety of complex behaviors, such as attentional focusing (the ability to concentrate attention on environmental cues relevant to the task in hand, or to switch attention from one task to another). Poor attentional focusing is a defining characteristic of autism.


"What is unique about the locus coeruleus is that it activates almost all higher-order brain centers that are involved in complex cognitive tasks," says Dr. Mehler.


Drs. Purpura and Mehler hypothesize that in autism, the LC-NA system is dysregulated by the interplay of environment, genetic, and epigenetic factors (chemical substances both within as well as outside the genome that regulate the expression of genes). They believe that stress plays a central role in dysregulation of the LC-NA system, especially in the latter stages of prenatal development when the fetal brain is particularly vulnerable.


As evidence, the researchers point to a 2008 study, published in the Journal of Autism and Developmental Disorders, that found a higher incidence of autism among children whose mothers had been exposed to hurricanes and tropical storms during pregnancy. Maternal exposure to severe storms at mid-gestation resulted in the highest prevalence of autism.


Drs. Purpura and Mehler believe that, in autistic children, fever stimulates the LC-NA system, temporarily restoring its normal regulatory function. "This could not happen if autism was caused by a lesion or some structural abnormality of the brain," says Dr. Purpura.


"This gives us hope that we will eventually be able to do something for people with autism," he adds.


The researchers do not advocate fever therapy (fever induced by artificial means), which would be an overly broad, and perhaps even dangerous, remedy. Instead, they say, the future of autism treatment probably lies in drugs that selectively target certain types of noradrenergic brain receptors or, more likely, in epigenetic therapies targeting genes of the LC-NA system.


"If the locus coeruleus is impaired in autism, it is probably because tens or hundreds, maybe even thousands, of genes are dysregulated in subtle and complex ways," says Dr. Mehler. "The only way you can reverse this process is with epigenetic therapies, which, we are beginning to learn, have the ability to coordinate very large integrated gene networks.
"

"The message here is one of hope but also one of caution," Dr. Mehler adds. "You can't take a complex neuropsychiatric disease that has escaped our understanding for 50 years and in one fell swoop have a therapy that is going to reverse it — that's folly. On the other hand, we now have clues to the neurobiology, the genetics, and the epigenetics of autism. To move forward, we need to invest more money in basic science to look at the genome and the epigenome in a more focused way.
"

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